发明授权
- 专利标题: Intermediates and process for producing fluorine-containing amino acid compound by using the same
- 专利标题(中): 中间体及使用它们的含氟氨基酸化合物的制造方法
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申请号: US09857631申请日: 2001-06-07
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公开(公告)号: US06392086B1公开(公告)日: 2002-05-21
- 发明人: Atsuro Nakazato , Toshihito Kumagai , Kazunari Sakagami , Kazuyuki Tomisawa , Hisanako Ito , Takeo Taguchi
- 申请人: Atsuro Nakazato , Toshihito Kumagai , Kazunari Sakagami , Kazuyuki Tomisawa , Hisanako Ito , Takeo Taguchi
- 优先权: JP10-361701 19981218
- 主分类号: C07C6974
- IPC分类号: C07C6974
摘要:
The present inventions relate to a (1S,5R,6S)- or (1SR, 5RS, 6SR)-3-fluoro-2-oxobicyclo[3.1.0]hex-3-ene-6-carboxylic acid derivative represented by Formula (1): [in the formula, R represents OR1 or NR1R2, wherein R1 and R2 are identical or different, and each represents a hydrogen atom, a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a (C3-C6 cycloalkyl) (C1-C6 alkyl) group, an aryl group, an aryl (C1-C6 alkyl) group, a (C1-C6 alkoxy) (C1-C6 alkyl) group, a C1-C6 hydroxyalkyl group, a (C1-C6 alkylthio) (C1-C6 alkyl) group, or a C1-C6 mercaptoalkyl group], and a process for producing the same, and a process for efficiently producing a fluorine-containing amino acid compound acting on group 2 metabotropic glutamate receptors, which has treatment effects or prevention effects on psychiatric diseases or neurological diseases, characterized by hydrogenating the derivative, and subsequently, subjecting it to hydantoination or aminocyanidation, followed by hydrolysis.
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