- 专利标题： Inhibitors of prenyl-protein transferase
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申请号： US09347673申请日： 1999-06-29
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公开(公告)号： US06410534B1公开(公告)日： 2002-06-25
- 发明人: Christopher J. Dinsmore , Ian M. Bell , Douglas C. Beshore , Theresa M. Williams
- 申请人： Christopher J. Dinsmore , Ian M. Bell , Douglas C. Beshore , Theresa M. Williams
- 主分类号： A61K314188
- IPC分类号： A61K314188
摘要：
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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