发明授权
- 专利标题： &agr;(1,3) galactosyltransferase negative porcine cells
- 专利标题（中）： α（1,3）半乳糖基转移酶阴性猪细胞
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申请号： US08929940申请日： 1997-09-15
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公开(公告)号： US06413769B1公开(公告)日： 2002-07-02
- 发明人: Kenth T. Gustafsson , David H. Sachs , Manfred W. Baetscher
- 申请人： Kenth T. Gustafsson , David H. Sachs , Manfred W. Baetscher
- 主分类号： C12N500
- IPC分类号： C12N500
摘要：
Transgenic swine in which the normal expression of &agr;(1, 3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Gal&agr;1-3Gal&bgr;1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
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