发明授权
- 专利标题： Inhibitors of prenyl-protein transferase
- 专利标题（中）： 异戊烯基蛋白转移酶的抑制剂
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申请号： US09757213申请日： 2001-01-09
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公开(公告)号： US06413964B1公开(公告)日： 2002-07-02
- 发明人: S. Jane deSolms , Suzanne C. MacTough , Anthony W. Shaw
- 申请人： S. Jane deSolms , Suzanne C. MacTough , Anthony W. Shaw
- 主分类号： A61K3155
- IPC分类号： A61K3155
摘要：
The present invention is directed to peptidomimetic macrocyclic compounds of the formula A: wherein W is a heterocycle, V is a heterocycle or aryl moiety and Z1 is a suitably substituted aryl or heterocycle moiety. The instant compounds inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.