发明授权
US06414153B1 1-phenylpydrrolidin-2-ones and -thiones and 1-(4-pyridyl)pydrrolidin-2-ones and -thiones which are useful in the treatment of inflammatory disease
有权
可用于治疗炎性疾病的1-苯基吡咯烷-2-酮和1-硫杂环戊二烯和1-（4-吡啶基）吡咯烷-2-酮和硫杂
- 专利标题： 1-phenylpydrrolidin-2-ones and -thiones and 1-(4-pyridyl)pydrrolidin-2-ones and -thiones which are useful in the treatment of inflammatory disease
- 专利标题（中）： 可用于治疗炎性疾病的1-苯基吡咯烷-2-酮和1-硫杂环戊二烯和1-（4-吡啶基）吡咯烷-2-酮和硫杂
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申请号： US09605584申请日： 2000-06-28
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公开(公告)号： US06414153B1公开(公告)日： 2002-07-02
- 发明人: Terence Alfred Kelly , Jiang-Ping Wu , Daniel Kuzmich , Yancey David Ward , Leah Lynn Frye
- 申请人： Terence Alfred Kelly , Jiang-Ping Wu , Daniel Kuzmich , Yancey David Ward , Leah Lynn Frye
- 主分类号： C07D47102
- IPC分类号： C07D47102
摘要：
Novel compounds of the formula I: which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-1,3-dihydroindol-2-one; 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydro-indol-2-one; 3-benzyl-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydroindol-2-one; 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-4-hydroxy-3-methyl-1,3-dihydroindol-2-one; and, 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-fluoro-1,3-dihydroindol-2-one.