Message-passing capability is provided in a computer system with a plurality of asynchronous computing nodes interconnected for transmission of messages between threaded user tasks executing in ones of the computing nodes. A message is received at a receiver computing node employing a threaded message passing interface (MPI), which includes a means by which a user-defined program can be called by an interrupt service thread at the MPI. The user-defined program takes a predefined action in response to the asynchronous arrival of the at least one message packet. For example, the user-defined program might comprise a program to initiate a function to receive the at least one message packet at the receiver's threaded MPI, which may include awaking a waiting thread.