A thermally-regulated bottle has a generally cylindrical body portion defining a first chamber for containing a drinking fluid and defining a central longitudinal axis. A passage is provided for accessing the drinking fluid. A secondary thermal-regulating container contains a thermal-regulating material, such as ice water, or heated water. According to a first embodiment of the invention, the bottle includes a recess which is positioned generally parallel to and remote from the central longitudinal axis, along the side of the bottle. The recess being sized and shaped to selectively receive the secondary thermal-regulating container so that the thermal-regulating material may thermally interact with the drinking fluid located within the chamber and either keep the drinking fluid heated or chilled with respect to the ambient temperature for a prolonged period of time. According to a second embodiment of the invention, the bottle includes a centrally located chamber which is sized and shaped to snugly receive the secondary container from an access opening located at the bottom of the bottle. Regardless of the arrangement, the heated or chilled material of the secondary container thermally reacts with the drinking fluid of the bottle and maintains either a chilled or heated temperature, as desired.