发明授权
- 专利标题： Human DNA mismatch repair proteins
- 专利标题（中）： 人类DNA错配修复蛋白
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申请号： US08468024申请日： 1995-06-06
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公开(公告)号： US06416984B1公开(公告)日： 2002-07-09
- 发明人: William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
- 申请人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
- 主分类号： C12N900
- IPC分类号： C12N900
摘要：
The invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.