发明授权
US06417158B1 Method of ameliorating the harmful effects of TNF using a polypeptide having the ability to bind to TNF
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使用具有结合TNF能力的多肽来改善TNF的有害作用的方法
- 专利标题： Method of ameliorating the harmful effects of TNF using a polypeptide having the ability to bind to TNF
- 专利标题（中）： 使用具有结合TNF能力的多肽来改善TNF的有害作用的方法
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申请号： US08477638申请日： 1995-06-07
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公开(公告)号： US06417158B1公开(公告)日： 2002-07-09
- 发明人: Rudolf Hauptmann , Adolf Himmler , Ingrid Maurer-Fogy , Christian Stratowa
- 申请人： Rudolf Hauptmann , Adolf Himmler , Ingrid Maurer-Fogy , Christian Stratowa
- 优先权： DE3913101 19890421; DE3920282 19890621; EP90106624 19900406
- 主分类号： A61K3819
- IPC分类号： A61K3819
摘要：
DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
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