A method and apparatus for setting registration in a multicolor printing machine having a number of exposure devices for the digital production of color separations, the actions of setting up and combining the color separations being controlled, in order to set the registration, in such a way that accurate registered prints are achieved. According to the invention, in the event of a change in the toner profile, the influence of the toner profile on the registration is taken into account, by available influencing variables directly as the change is implemented.