发明授权
- 专利标题： &agr; v integrin receptor antagonists
- 专利标题（中）： αv整联蛋白受体拮抗剂
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申请号： US09952084申请日： 2001-09-14
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公开(公告)号： US06426353B1公开(公告)日： 2002-07-30
- 发明人: Byron H. Arison , Donghui Cui , Mark E. Duggan , Wasyl Halczenko , John H. Hutchinson , Thomayant Prueksaritanont , Raju Subramanian , Xiaojun Fang
- 申请人： Byron H. Arison , Donghui Cui , Mark E. Duggan , Wasyl Halczenko , John H. Hutchinson , Thomayant Prueksaritanont , Raju Subramanian , Xiaojun Fang
- 主分类号： A61K31435
- IPC分类号： A61K31435
摘要：
The present invention relates to novel compounds formed by metabolic conversion of compounds of structural formula (1), pharmaceutical compositions containing such compounds, and their use as &agr;v&bgr;3 integrin receptor antagonists. The compounds of the present invention are useful for inhibiting bone resorption, restenosis, angiogenesis, diabetic retinopathy, macular degeneration, inflammatory arthritis, cancer, and metastatic tumor growth. They are particularly useful for inhibiting bone resorption and for the treatment and prevention of osteoporosis.
公开/授权文献
- US20020049224A1 Alpha v integrin receptor antagonists 公开/授权日：2002-04-25