发明授权
US06434489B1 Compositions of hepatitis C virus NS5B polymerase and methods for crystallizing same
失效
丙型肝炎病毒NS5B聚合酶的组合物及其结晶方法
- 专利标题： Compositions of hepatitis C virus NS5B polymerase and methods for crystallizing same
- 专利标题（中）： 丙型肝炎病毒NS5B聚合酶的组合物及其结晶方法
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申请号： US09541990申请日： 2000-04-03
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公开(公告)号： US06434489B1公开(公告)日： 2002-08-13
- 发明人: Charles A. Lesburg , Michael Cable , Zhi Hong , Anthony F. Mannarino , Patricia C. Weber
- 申请人： Charles A. Lesburg , Michael Cable , Zhi Hong , Anthony F. Mannarino , Patricia C. Weber
- 主分类号： G01N3348
- IPC分类号： G01N3348
摘要：
The invention relates to the purification, crystallization of and structure of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. Also, crystallization conditions for NS5B are provided. Further, the atomic coordinates for the NS5B protein are disclosed. Examples of its use for the determination of the three-dimensional atomic structures of HCV NS5B or HCV NS5B in complex with substrates or substrate analogs or inhibitors are also provided.
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