发明授权
US06441135B1 Bak binding protein, DNA encoding the protein, and methods of use thereof
有权
Bak结合蛋白，编码蛋白的DNA及其使用方法
- 专利标题： Bak binding protein, DNA encoding the protein, and methods of use thereof
- 专利标题（中）： Bak结合蛋白，编码蛋白的DNA及其使用方法
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申请号： US09381488申请日： 2000-02-11
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公开(公告)号： US06441135B1公开(公告)日： 2002-08-27
- 发明人: Michael C. Kiefer , Paul A. Fitzpatrick , Helen L. Gibson , Philip J. Barr
- 申请人： Michael C. Kiefer , Paul A. Fitzpatrick , Helen L. Gibson , Philip J. Barr
- 主分类号： C07K100
- IPC分类号： C07K100
摘要：
The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to BBP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention neither provides methods for detecting the presence of bbp or BBP in a biological sample, and further provides methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the “BBP Binding Domains” and the respective nucleotides, designated “bbpbd-1” and “bbpbd-2” which arc involved in the interaction between Bak and BBP.
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