发明授权
US06444677B2 5-membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists
失效
5元杂芳基取代的1,4-二氢吡啶化合物作为缓激肽拮抗剂
- 专利标题: 5-membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists
- 专利标题(中): 5元杂芳基取代的1,4-二氢吡啶化合物作为缓激肽拮抗剂
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申请号: US09731995申请日: 2000-12-07
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公开(公告)号: US06444677B2公开(公告)日: 2002-09-03
- 发明人: Takafumi Ikeda , Mitsuhiro Kawamura , Noriaki Murase , Seiji Nukui , Yuji Shishido , Makato Kawai , Yoshiyuki Okumura
- 申请人: Takafumi Ikeda , Mitsuhiro Kawamura , Noriaki Murase , Seiji Nukui , Yuji Shishido , Makato Kawai , Yoshiyuki Okumura
- 主分类号: C07D40100
- IPC分类号: C07D40100
摘要:
This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof wherein A is independently halo; Y1 is —(CH2)m—, C(O) or S(O); Y2 is N or CH; R1 and R2 are independently C1-4 alkyl; R3 is selected from the following: (a) optionally substituted —(CH2)p—C3-7 cycloalkyl; (b) optionally substituted —C5-7 alkyl; and (c) substituted —C1-4 alkyl; and (d) optionally substituted C7-9 bicycloalkyl; R4 is optionally substituted thiazolyl, imidazolyl or oxazolyl; X is S, —NH, —N—C1-4 alkyl or O; R5 is hydrogen or C1-4 alkyl; R6 is C1-4 alkyl or halo; m is 0, 1 or 2; n is 0, 1, 2, 3, 4 or S; and p is 0, 1, 2, 3, 4, 5 or 6. These compounds are useful for the treatment of medical conditions caused by bradykinin such as inflammation, cardiovascular disease, pain, etc. This invention also provides a pharmaceutical composition comprising the above compound.