发明授权
- 专利标题: Compounds useful as neuro-protective agents
- 专利标题(中): 可用作神经保护剂的化合物
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申请号: US09159346申请日: 1998-09-23
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公开(公告)号: US06448396B2公开(公告)日: 2002-09-10
- 发明人: Benjamin Alan Anderson , Lawrence Joseph Heinz , Jill Ann Panetta , Michael LeRoy Phillips , John Allan Rieck, III , John Robert Rizzo , John Kevin Shadle , David Lee Varie
- 申请人: Benjamin Alan Anderson , Lawrence Joseph Heinz , Jill Ann Panetta , Michael LeRoy Phillips , John Allan Rieck, III , John Robert Rizzo , John Kevin Shadle , David Lee Varie
- 主分类号: C07D41312
- IPC分类号: C07D41312
摘要:
The present invention provides a process of preparing a compound of the formula IV wherein: R1 and R2 are each individually -(C1-C6)alkyl, -(C1-C6)alkoxy or phenyl, R3 is H or -(C1-C6)alkyl, R6 is —NR7R8, morpholin-1-yl, imidazol-1-yl, 4,5-dihydro-1H-imidazol-2-yl, thiomorpholin-1-yl, piperazin-1-yl or piperazin-1-yl substituted with -(C1-C4)alkyl or and R7 and R8 are each individually hydrogen, -(C1-C6)alkyl, —(CH2)pOH, —(CH2)p-piperidyl, —(CH2)pS(C1-C6)alkyl, —(CH2)pO(C1-C6)alkyl where R9 is (C1-C6)alkyl; P is an integer from 1-3 both inclusive; q is 0 or 1; and t is 1 to 6 both inclusive; or a pharmaceutically acceptable salt, hydrate or optical isomer thereof, which is useful as a neuroprotective agent.
公开/授权文献
- US20010027194A1 NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS 公开/授权日:2001-10-04
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