发明授权
US06451305B1 Methods for stimulating T cell responses to tumor cells expressing LFA-3 and a CD28 or CTLA4 ligand
失效
刺激表达LFA-3和CD28或CTLA4配体的肿瘤细胞的T细胞应答的方法
- 专利标题： Methods for stimulating T cell responses to tumor cells expressing LFA-3 and a CD28 or CTLA4 ligand
- 专利标题（中）： 刺激表达LFA-3和CD28或CTLA4配体的肿瘤细胞的T细胞应答的方法
-
申请号： US08457483申请日： 1995-06-01
-
公开(公告)号： US06451305B1公开(公告)日： 2002-09-17
- 发明人: Vassiliki A. Boussiotis , Gordon J. Freeman , Lee M. Nadler
- 申请人： Vassiliki A. Boussiotis , Gordon J. Freeman , Lee M. Nadler
- 主分类号： A61K4800
- IPC分类号： A61K4800
摘要：
Methods for stimulating a T cell response to a tumor cell in a subject with a tumor which involve modifying the tumor cell to express a CD2 ligand and a CD28 or CTLA4 ligand, are disclosed. Methods wherein the tumor cell is obtained from the subject and modified ex vivo to form a modified tumor cell and then the modified tumor cell is administered to the subject, are also disclosed.
信息查询
