发明授权
- 专利标题： Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
- 专利标题（中）： 能够抑制表皮生长因子受体家族酪氨酸激酶的双环化合物
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申请号： US09824606申请日： 2001-04-02
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公开(公告)号： US06455534B2公开(公告)日： 2002-09-24
- 发明人: Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson
- 申请人： Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson
- 主分类号： A61K31519
- IPC分类号： A61K31519
摘要：
Described are compounds and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II: where: one of A or E is nitrogen, with remaining atoms carbon; X=O, S, NH or NR7, such that R7=lower alkyl (1-4 carbon atoms), OH, NH2, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms). Other terms are described in the specification.
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