Invention Grant
US06455577B2 Flavanone derivatives and composition for preventing or treating blood lipid level-related diseases comprising same 失效
用于预防或治疗包含其的血脂水平相关疾病的黄酮酮衍生物和组合物

Flavanone derivatives and composition for preventing or treating blood lipid level-related diseases comprising same
Abstract:
A compound of formula (I) treating or preventing an elevated blood lipid level-related disease and inhibiting the activities of acyl-CoA:cholesterol-O-acyltransferase(ACAT) and 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase: wherein, R1 is R5 R6CO group; R2 is H or R6CO group; R3 is H, CH3, R5 or R6CO group; R4 is H, OH, OR5 or R6COO group; R5 is a C2-5 alkyl group substituted with a phenyl group optionally having one or more substituents selected from the group consisting of C1-3 alkyl, OH, Cl and NO2; a C1-5 alkyl group substituted with a naphthyl group optionally having one or more substituents selected from the group consisting of C1-3 alkyl, OH, Cl and NO2; a C10-18 alkyl; or a C10-18 alkenyl group; and R6 is a C10-18 alkenyl group; or an aryl group optionally having one or more substituents selected from the group consisting of C1-3 alkyl, OH, Cl or NO2.
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