Invention Grant
US06455577B2 Flavanone derivatives and composition for preventing or treating blood lipid level-related diseases comprising same
失效
用于预防或治疗包含其的血脂水平相关疾病的黄酮酮衍生物和组合物
- Patent Title: Flavanone derivatives and composition for preventing or treating blood lipid level-related diseases comprising same
- Patent Title (中): 用于预防或治疗包含其的血脂水平相关疾病的黄酮酮衍生物和组合物
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Application No.: US09768740Application Date: 2001-01-24
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Publication No.: US06455577B2Publication Date: 2002-09-24
- Inventor: Song-Hae Bok , Tae-Sook Jeong , Sang-Ku Lee , Ju-Ryong Kim , Surk-Sik Moon , Myung-Sook Choi , Byung-Hwa Hyun , Chul-Ho Lee , Yang-Kyu Choi
- Applicant: Song-Hae Bok , Tae-Sook Jeong , Sang-Ku Lee , Ju-Ryong Kim , Surk-Sik Moon , Myung-Sook Choi , Byung-Hwa Hyun , Chul-Ho Lee , Yang-Kyu Choi
- Priority: KR2000-87185 20001230
- Main IPC: A61K3135
- IPC: A61K3135

Abstract:
A compound of formula (I) treating or preventing an elevated blood lipid level-related disease and inhibiting the activities of acyl-CoA:cholesterol-O-acyltransferase(ACAT) and 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase: wherein, R1 is R5 R6CO group; R2 is H or R6CO group; R3 is H, CH3, R5 or R6CO group; R4 is H, OH, OR5 or R6COO group; R5 is a C2-5 alkyl group substituted with a phenyl group optionally having one or more substituents selected from the group consisting of C1-3 alkyl, OH, Cl and NO2; a C1-5 alkyl group substituted with a naphthyl group optionally having one or more substituents selected from the group consisting of C1-3 alkyl, OH, Cl and NO2; a C10-18 alkyl; or a C10-18 alkenyl group; and R6 is a C10-18 alkenyl group; or an aryl group optionally having one or more substituents selected from the group consisting of C1-3 alkyl, OH, Cl or NO2.
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