发明授权
- 专利标题： Methods and compositions for the inhibition of cancer metastasis mediated by endothelial adhesion molecules
- 专利标题（中）： 用于抑制内皮粘附分子介导的癌转移的方法和组合物
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申请号： US09447532申请日： 1999-11-23
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公开(公告)号： US06465434B1公开(公告)日： 2002-10-15
- 发明人: John L. Magnani , Eugene C. Butcher , Ellen L. Berg
- 申请人： John L. Magnani , Eugene C. Butcher , Ellen L. Berg
- 主分类号： A01N4304
- IPC分类号： A01N4304
摘要：
Methods and compositions are disclosed for the inhibition of cancer metastases mediated by endothelial adhesion molecules. The present invention discloses that sialyl Lea and di-sialyl Lea, which are expressed at the surface of cancer cells, function as a binding partner for LEC-CAMs, such as ELAM-1, which are expressed at the surface of endothelial cells. The present invention also discloses that LEC-CAMs, such as ELAM-1, involved in cancer metastasis share a carbohydrate domain common to both sialyl Lea and sialyl Lex. Antibodies, saccharides, glycoconjugates, enzyme inhibitors and other compounds may be used in the methods of the present invention to inhibit the binding of malignant cells to endothelial cells for a variety of purposes in vivo and in vitro.
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