发明授权
US06468732B1 METHOD AND LONG-TERM STABLE BICARBONATE-CONTAINING DILUENT COMPOSITION, AND STORAGE MEANS THEREFOR, FOR REDUCING OR REVERSING AERATION INDUCED CELL SHRINKAGE AND STORAGE INDUCED CELL SWELLING OF A WHOLE BLOOD SAMPLE
有权
方法和长期稳定的含二碳酸酯的稀释剂组合物及其储存方法，用于减少或逆转诱导的细胞收缩和储存诱导的全血样品的细胞裂解
- 专利标题： METHOD AND LONG-TERM STABLE BICARBONATE-CONTAINING DILUENT COMPOSITION, AND STORAGE MEANS THEREFOR, FOR REDUCING OR REVERSING AERATION INDUCED CELL SHRINKAGE AND STORAGE INDUCED CELL SWELLING OF A WHOLE BLOOD SAMPLE
- 专利标题（中）： 方法和长期稳定的含二碳酸酯的稀释剂组合物及其储存方法，用于减少或逆转诱导的细胞收缩和储存诱导的全血样品的细胞裂解
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申请号： US09819263申请日： 2001-03-28
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公开(公告)号： US06468732B1公开(公告)日： 2002-10-22
- 发明人: Michael J. Malin , Leonard Ornstein
- 申请人： Michael J. Malin , Leonard Ornstein
- 主分类号： A01N102
- IPC分类号： A01N102
摘要：
The invention provides a bicarbonate-containing, crosslinker-free reagent composition which reverses and/or reduces sample handling effects, such as aeration-induced shrinkage and storage-induced swelling of cells in a whole blood sample, particularly for a blood sample requiring repeated sampling and/or subjected to long-term storage. The reagent composition serves as a diluent medium for a blood sample, or an aliquot or portion thereof. The pH of the reagent is in the range of about 7.2 to about 7.5, preferably 7.3. The stability of the pH 7.2-7.5 bicarbonate-containing reagent over time is maintained by storing the reagent in a flexible collapsible container which is impermeable to carbon dioxide and is comprised of a multilayered flexible material, preferably plastic, and attachable to a hematology analyzer.
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