发明授权
US06468966B1 Octacyclodepsipeptides having an endoparasiticidal action
失效
具有内寄生性杀伤作用的Octacyclodepsipeptide
- 专利标题: Octacyclodepsipeptides having an endoparasiticidal action
- 专利标题(中): 具有内寄生性杀伤作用的Octacyclodepsipeptide
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申请号: US08246022申请日: 1994-05-19
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公开(公告)号: US06468966B1公开(公告)日: 2002-10-22
- 发明人: Jürgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
- 申请人: Jürgen Scherkenbeck , Peter Jeschke , Hans-Georg Lerchen , Hermann Hagemann , Achim Harder , Norbert Mencke , Andrew Plant
- 优先权: DEP4317432 19930526
- 主分类号: A61K3800
- IPC分类号: A61K3800
摘要:
The present invention relates to compounds of the general formula (I) in which R1 and R12 represent the same or different radicals selected from the group of C2-9-alkyl, C1-8-halogen-alkyl, C3-6-cycloalkyl, aralkyl or aryl, R3 to R10 represent the same or different radicals selected from the group of hydrogen, C1-5-alkyl which may optionally be substituted by hydroxyl, alkoxy, carboxyl, carboxamide, imidazolyl, indolyl, guanidino, thio- or thioalkyl, and represent aryl, alkylaryl or heteroarylmethyl which are optionally substituted by halogen, hydroxyl, alkyl, alkoxy, nitro or a —NR13R14 group in which R13 or R14 independently from each other represent hydrogen or alkyl or together with the adjoining nitrogen atom form a 5, 6 or 7-membered ring which is optionally interrupted by O, S or N and which is optionally substituted by C1-4-alkyl, R2 and R11 represent the same of different radicals selected from the group of C1-4-alkyl, and stereoisomers thereof, to processes for their preparation and to their use as endoparasiticides.