发明授权
- 专利标题: Cephem compounds
- 专利标题(中): 头孢烯化合物
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申请号: US08781924申请日: 1996-12-30
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公开(公告)号: US06468995B1公开(公告)日: 2002-10-22
- 发明人: Kohji Kawabata , Takeshi Terasawa , Ayako Ohki , Fumiyuki Shirai , Hirofumi Yamamoto
- 申请人: Kohji Kawabata , Takeshi Terasawa , Ayako Ohki , Fumiyuki Shirai , Hirofumi Yamamoto
- 优先权: GB9318678 19930909; GB9325104 19931208; GB9326612 19931231
- 主分类号: C07D50134
- IPC分类号: C07D50134
摘要:
A compound of the formula: wherein R1 is amino or protected amino; R2 is hydrogen, lower alkyl or hydroxy protective group; R3 is carboxy or protected carboxy; R4 is an unsubstituted 5, 6 or 7-membered heteromonocyclic group containing two nitrogen atoms as heteroatoms, and which optionally further contains one oxygen or sulfur atom; or R4 is said 5, 6 or 7-membered heteromonocyclic group substituted by 1 to 4 groups selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, lower alkylamino, cyclo(lower)alkyl, cyclo(lower)alkenyl, halogen, amino, protected amino, protected hydroxy, cyano, nitro, carboxy, hydroxy(lower)alkyl, amino(lower)alkyl, and carbamoyloxy; and n is 1 or 2.