发明授权
- 专利标题: &agr;V integrin receptor antagonists
- 专利标题(中): αV整联蛋白受体拮抗剂
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申请号: US09766148申请日: 2001-01-19
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公开(公告)号: US06472403B2公开(公告)日: 2002-10-29
- 发明人: Mark E. Duggan , Wasyl Halczenko , John H. Hutchinson , Aiwen Li , Robert S. Meissner , James J. Perkins , Thomas G. Steele , Jiabing Wang , Michael A. Patane
- 申请人: Mark E. Duggan , Wasyl Halczenko , John H. Hutchinson , Aiwen Li , Robert S. Meissner , James J. Perkins , Thomas G. Steele , Jiabing Wang , Michael A. Patane
- 主分类号: A61K3144
- IPC分类号: A61K3144
摘要:
The present invention relates to novel imidazolidinone derivatives thereof, their synthesis, and their use as &agr;v integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors &agr;v&bgr;3 and/or &agr;v&bgr;5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.
公开/授权文献
- US20020037889A1 Alpha V integrin receptor antagonists 公开/授权日:2002-03-28