发明授权
- 专利标题： Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same
- 专利标题（中）： 具有成骨活性的合成肽和假肽以及含有它们的药物组合物
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申请号： US09150621申请日： 1998-09-10
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公开(公告)号： US06479460B1公开(公告)日： 2002-11-12
- 发明人: Itai Bab , Dan Gazit , Chen Yu-Chen , Andras Muhlrad , Arie Shteyer , Michael Chorev
- 申请人： Itai Bab , Dan Gazit , Chen Yu-Chen , Andras Muhlrad , Arie Shteyer , Michael Chorev
- 优先权： IL117426 19960310
- 主分类号： A61K3808
- IPC分类号： A61K3808
摘要：
The invention relates to synthetic pseudopeptide derivatives of osteogenic grog polypeptide (OGP) and OGP(10-14) which may be linear or cyclic, and which are capable of enhancing bone cell proliferation and bone formation. Further, the present invention relates to pharmaceutical composition comprising as active ingredient at least one pseudopeptide derivative of the invention and to the use of these pseudopeptide derivatives in the preparation of a pharmaceutical composition for stimulating the formation of osteoblastic or fibroblastic cells, enhancing bone formation in osteopenic pathological conditions, repairing fractures, healing wounds, grafting of intraosseous implants, reversing bone loss in osteoporosis and other conditions requiring enhanced bone cells formation.
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