发明授权
- 专利标题: Antibodies to ARF-p19
- 专利标题(中): ARF-p19的抗体
-
申请号: US09610833申请日: 2000-07-06
-
公开(公告)号: US06482929B1公开(公告)日: 2002-11-19
- 发明人: Charles J. Sherr , Dawn E. Quelle
- 申请人: Charles J. Sherr , Dawn E. Quelle
- 主分类号: C07K1600
- IPC分类号: C07K1600
摘要:
The INK4A (MTS1, CDKN2) gene encodes a specific inhibitor (InK4a-p16) of the cyclin D-dependent kinases CDK4 and CDK6. InK4a-p16 can block these kinase from phosphorylating the retinoblastoma protein (pRb), preventing exit from the G1 phase of the cell cycle. Deletions and mutations involving the gene encoding InK4a-p16, INK4A, occur frequently in cancer cells, implying that INK4a-p16, like pRb, suppresses tumor formulation. However, a completely unrelated protein (ARF-p19) arises in major part from an alternative reading frame of the mouse INK4A gene. Expression of an ARF-p19 cDNA (SEQ ID NO:1) in rodent fibroblasts induces both G1 and G2 phase arrest.