发明授权
![N-[4-(heteroarylmethyl)phenyl]-heteroarylamines](/docs/US/2002-11-26/US06486187B1/abs.jpg.600x600.jpg)
- 专利标题： N-[4-(heteroarylmethyl)phenyl]-heteroarylamines
- 专利标题（中）： N- [4-（杂芳基甲基）苯基] - 杂芳基胺
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申请号： US09624966申请日： 2000-07-25
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公开(公告)号： US06486187B1公开(公告)日： 2002-11-26
- 发明人: Marc Gaston Venet , Dominique Jean-Pierre Mabire , Jean Fernand Armand Lacrampe , Gerard Charles Sanz
- 申请人： Marc Gaston Venet , Dominique Jean-Pierre Mabire , Jean Fernand Armand Lacrampe , Gerard Charles Sanz
- 优先权： EP96201781 19960627
- 主分类号： A61K31422
- IPC分类号： A61K31422
![N-[4-(heteroarylmethyl)phenyl]-heteroarylamines](/abs-image/US/2002/11/26/US06486187B1/abs.jpg.150x150.jpg)
摘要：
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-6alkyl or aryl; R2 is hydrogen; optionally substituted C1-12alkyl; C3-7cycloalkyl; C2-8alkenyl, optionally substituted pyrrolidinyl or aryl; R3 is hydrogen, optionally substituted C1-6alkyl or aryl; Het is an optionally substituted unsaturated heterocycle selected from imidazolyl, triazolyl, tetrazolyl and pyridinyl; is an optionally substituted unsaturated mono- or bicyclic heterocycle; and aryl is optionally substituted phenyl. The present invention also relates to processes for their preparation and compositions comprising said new compounds, as well as their use as a medicine.