Disclosed herein are a display device and a method of driving the same, more particular, the present invention provides a display device comprising display media each of which has a dispersion medium and a large number of electrophoretic particles dispersed in the dispersion medium, the electrophoretic particles being driven by applying an electric field to each of the display media, to thereby perform a desired display operation; wherein the electrophoretic particles comprise small-sized two-color ball electrophoretic particles each of which is composed of a pair of hemispherical portions different from each other in terms of color or reflectance and charging characteristic; and the dispersion medium comprises a colorless/transparent dispersion medium. With this configuration, it is possible to realize the display of clear white and true black, enhance the contrast ratio, realize high speed display switching, and perform multi-color display.