发明授权
- 专利标题: 2-piperidone compounds
- 专利标题(中): 2-哌啶酮化合物
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申请号: US09481542申请日: 2000-01-12
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公开(公告)号: US06492392B1公开(公告)日: 2002-12-10
- 发明人: Yutaka Kanda , Rieko Tanaka , Mitsunobu Hara , Jun Eishima , Shiro Akinaga , Tadashi Ashizawa
- 申请人: Yutaka Kanda , Rieko Tanaka , Mitsunobu Hara , Jun Eishima , Shiro Akinaga , Tadashi Ashizawa
- 主分类号: A61K31445
- IPC分类号: A61K31445
摘要:
The present invention provides 2-piperidone compounds or pharmaceutically acceptable salts thereof, which have a potent activity of inhibiting the proliferation of tumor cells and thus are useful as medicaments, as well as antitumor agents containing these compounds. The 2-piperidone compound is represented by the following formula (I): wherein R1 represents —(CH2)nR1a {wherein n is an integer of from 0 to 5, and R1a represents amino, lower alkylamino, di(lower alkyl)amino, substituted or unsubstituted aryl, or a substituted or unsubstituted heterocyclic group}, and R2 and R3 independently represent lower alkyl which may be substituted by lower alkoxycarboyl; lower alkenyl, aralkyl or lower alkynyl which may be substituted by substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; substituted or unsubstituted aryl; or a substituted or unsubstituted heterocyclic group.