A method of invalidating shared cache lines such as on a sharing list by issuing an invalidate acknowledgement before actually invalidating a cache line. The method is useful in multiprocessor systems such as a distributed shared memory (DSM) or non-uniform memory access (NUMA) machines that include a number of interconnected processor nodes each having local memory and caches that store copies of the same data. In such a multiprocessor system using the Scalable Content Interface (SCI) protocol, an invalidate request is sent from the head node on the sharing list to a succeeding node on the list. In response to the invalidate request, the succeeding node issues an invalidate acknowledgement before the cache line is actually invalidated. After issuing the invalidate acknowledgement, the succeeding node initiates invalidation of the cache line. The invalidate acknowledgement can take the form of a response to the head node or a forwarding of the invalidate request to the next succeeding node on the list. To maintain processor consistency, a flag is set each time an invalidate acknowledgement is sent. The flag is cleared after the invalidation of the cache line is completed. Cacheable transactions received at the succeeding node while a flag is set are delayed until the flag is cleared.