A printing unit is provided for a web fed printing machine having at least two cylinders where at least one of the cylinders is adjustable with respect to another of the cylinders; a machine frame having at least one load bearing wall arranged laterally beside an end of the cylinders; a drive motor corresponding to each cylinder; at least one guide element operably attached to the load bearing wall at a surface of the load bearing wall that runs perpendicular to a plane through the end faces of the cylinders; and a plurality of carriages attached to the guide element. At least one of the cylinders is connected to the carriages so that a distance from another of the cylinders can be adjusted.