Invention Grant
- Patent Title: Prodrugs for antimicrobial amidines
- Patent Title (中): 抗生素脒类药物
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Application No.: US09918787Application Date: 2001-07-31
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Publication No.: US06503940B2Publication Date: 2003-01-07
- Inventor: David W. Boykin , M. Syed Rahmathullah , Richard R. Tidwell , James E. Hall
- Applicant: David W. Boykin , M. Syed Rahmathullah , Richard R. Tidwell , James E. Hall
- Main IPC: A61K3140
- IPC: A61K3140

Abstract:
A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I): wherein: X may be O, S, or NR′ wherein R′ is H or loweralkyl, R1 and R2 may be independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl; R3 and R4 are each independently selected from the group consisting of H, loweralkyl, halogen, oxyalkyl, oxyaryl, and oxyarylalkyl; R5 is represented by a formula selected from the group consisting of: wherein: X1, X2, and X3 are independently selected from O and S; and R6 and R7 are independently selected from the group consisting of loweralkyl, aryl, alkylaryl, oxyaryl, an ester-containing substituent, and oxyalkyl; or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20020019437A1 Novel prodrugs for antimicrobial amidines Public/Granted day:2002-02-14
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