发明授权
- 专利标题: Substituted benzenesulfonylureas and -thioureas-processes for their preparation and their use as pharmaceuticals
- 专利标题(中): 取代苯磺酰脲和硫脲制备方法及其作为药物的用途
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申请号: US09995782申请日: 2001-11-29
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公开(公告)号: US06506937B2公开(公告)日: 2003-01-14
- 发明人: Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gögelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
- 申请人: Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gögelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
- 优先权: DE4305450 19930223
- 主分类号: C07C31116
- IPC分类号: C07C31116
摘要:
Benzenesulfonylureas and -thioureas of the formula I where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro) (mercapto)alk(oxy)yl, E is O or S; Y is —[CR(3)2]n—, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO3 or alk(yl)oxy, are described. The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used an antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
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