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发明授权
US06509337B1 Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors 失效
作为MMP和TNF抑制剂的芳基磺酰基羟肟酸衍生物

  • 专利标题： Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors
  • 专利标题（中）： 作为MMP和TNF抑制剂的芳基磺酰基羟肟酸衍生物
  • 申请号： US09154969
    申请日： 1998-09-17
  • 公开(公告)号： US06509337B1
    公开(公告)日： 2003-01-21
  • 发明人: Anthony Piscopio , James P. Rizzi
  • 申请人： Anthony Piscopio , James P. Rizzi
  • 主分类号： A61K31445
  • IPC分类号： A61K31445
Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors
摘要：
A compound of the formula wherein R1-R9 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidemrolysis bullosa, scleritis and other disease characterized by matrix metalloproteinase activity, as well as AIDS, sepsis, septic shock and other diseases involving the production of TNF.
摘要（中）：

式R 1 -R 9和Ar的化合物如上所定义，可用于治疗选自关节炎，癌症，组织溃疡，再狭窄，牙周病，流行性大疱性炎症，巩膜炎和其他以基质为特征的疾病 金属蛋白酶活性，以及​​艾滋病，败血症，败血性休克和涉及TNF产生的其他疾病。

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