发明授权
- 专利标题： Cross-linked antibodies and processes for their preparation
- 专利标题（中）： 交联抗体及其制备方法
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申请号： US08181396申请日： 1994-01-13
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公开(公告)号： US06509451B1公开(公告)日： 2003-01-21
- 发明人: Stephen K. Rhind
- 申请人： Stephen K. Rhind
- 优先权： GB8903021 19890210; GBPCT/GB90/00214 19900212
- 主分类号： C07K1600
- IPC分类号： C07K1600
摘要：
Bis-maleimido cross-linking reagents join labelled antibodies having at least one sulphide interchain bridge. The conjugates have an enhanced binding capacity and have good blood clearance in vivo. The conjugates are of use in the diagnosis and therapy of tumors and may be prepared by reaction of the cross-linking reagent with the antibody.
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