发明授权
- 专利标题： Nitrophenylaziridine compounds and their use as prodrugs
- 专利标题（中）： 硝基苯基氮丙啶化合物及其作为前药的用途
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申请号： US09786588申请日： 2001-03-06
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公开(公告)号： US06517836B1公开(公告)日： 2003-02-11
- 发明人: William Alexander Denny , Graham John Atwell , Brian Desmond Palmer , William Robert Wilson
- 申请人： William Alexander Denny , Graham John Atwell , Brian Desmond Palmer , William Robert Wilson
- 优先权： GB9819472 19980907
- 主分类号： A61K3944
- IPC分类号： A61K3944
摘要：
A range of aziridin-1-yl nitrobenzamides are provided for use as prodrugs in conjunction with nitroreductase (NR) enzymes. The amides may have 1 or 2-substituents which may be bulky and polar. For example, 5-(aziridin-1-yl)-N-[2-(4-morpholino)ethyl]-2,4-dinitrobenzamide of Formula (A) was found to be highly active against all NR+ cell lines tested.
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