发明授权
US06541008B1 Vascular endothelial growth factor-like protein from orf viruses binds and activates mammalian VEGF receptor-2, and uses thereof
失效
来自orf病毒的血管内皮生长因子样蛋白结合并激活哺乳动物VEGF受体-2及其用途
- 专利标题： Vascular endothelial growth factor-like protein from orf viruses binds and activates mammalian VEGF receptor-2, and uses thereof
- 专利标题（中）： 来自orf病毒的血管内皮生长因子样蛋白结合并激活哺乳动物VEGF受体-2及其用途
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申请号： US09431888申请日： 1999-11-02
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公开(公告)号： US06541008B1公开(公告)日： 2003-04-01
- 发明人: Lyn M. Wise , Andrew A. Mercer , Loreen J. Savory , Stephen B. Fleming , Steven A. Stacker
- 申请人： Lyn M. Wise , Andrew A. Mercer , Loreen J. Savory , Stephen B. Fleming , Steven A. Stacker
- 主分类号： A61K3900
- IPC分类号： A61K3900
摘要：
The invention is based on the discovery that a viral VEGF-like protein from the orf virus strain NZ2 and from the orf virus strain NZ10 is capable of binding to the extracellular domain of the VEGF receptor-2 to form bioactive complexes which mediate useful cellular responses and/or antagonize undesired biological activities. Disclosed are methods which stimulate or inhibit these biological activities, methods for therapeutic applications and antagonists of ORFV2-VEGF and/or NZ10.
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