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发明授权
US06541263B2 Determination of corticosteroids in human plasma using micromass LC/MS/MS 有权
使用微质LC / MS / MS测定人血浆中的皮质类固醇

  • 专利标题： Determination of corticosteroids in human plasma using micromass LC/MS/MS
  • 专利标题（中）： 使用微质LC / MS / MS测定人血浆中的皮质类固醇
  • 申请号： US09788353
    申请日： 2001-02-21
  • 公开(公告)号： US06541263B2
    公开(公告)日： 2003-04-01
  • 发明人: Feng Gao
  • 申请人： Feng Gao
  • 主分类号： G01N3392
  • IPC分类号： G01N3392
Determination of corticosteroids in human plasma using micromass LC/MS/MS
摘要：
The present invention is directed to a method of detecting a corticosteroid in a sample by adding an internal standard to a sample suspected of containing a corticosteroid; removing interfering compounds from the sample; placing the sample on an HPLC column equilibrated with a NH4OAc:MeOH solution and collecting an eluent; and analyzing the eluent of the HPLC column with a MS, wherein if contained in the sample, the corticosteroid forms an adduct that is detected by the MS.
摘要（中）：

本发明涉及通过向怀疑含有皮质类固醇的样品添加内标而检测样品中皮质类固醇的方法; 从样品中除去干扰化合物; 将样品置于用NH 4 OAc·MeOH溶液平衡的HPLC柱上并收集洗脱剂; 并用MS分析HPLC柱的洗脱液，其中如果包含在样品中，皮质类固醇形成由MS检测的加合物。

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