发明授权
US06544977B1 CRYSTALLINE FORMS OF 1S-[1-ALPHA(2S*,3R*), 9ALPHA]6, 10-DIOXO-N-(2-ETHOXY-5-OXO-TETRAHYDRO-3-FURANYL)-9[[(1-ISOQUINOLYL)CARBONYL]AMINO]OCTAHYDRO-6H-PYRIDAZINO [1,2-A] [1,2] DIAZEPIN-1-CARBOXAMIDE
有权
1S- [1-ALPHA（2S *，3R *），9ALPHA] 6,10-二氧代-N-（2-乙氧基-5-氧代四氢呋喃-3-基）-9] [[（1-异喹啉 ）羰基]氨基]甲酰基-6H-吡啶并[1,2-A] [1,2]二氮杂-1-羧酸
![CRYSTALLINE FORMS OF 1S-[1-ALPHA(2S*,3R*), 9ALPHA]6, 10-DIOXO-N-(2-ETHOXY-5-OXO-TETRAHYDRO-3-FURANYL)-9[[(1-ISOQUINOLYL)CARBONYL]AMINO]OCTAHYDRO-6H-PYRIDAZINO [1,2-A] [1,2] DIAZEPIN-1-CARBOXAMIDE](/docs/US/2003-04-08/US06544977B1/abs.jpg.600x600.jpg)
- 专利标题： CRYSTALLINE FORMS OF 1S-[1-ALPHA(2S*,3R*), 9ALPHA]6, 10-DIOXO-N-(2-ETHOXY-5-OXO-TETRAHYDRO-3-FURANYL)-9[[(1-ISOQUINOLYL)CARBONYL]AMINO]OCTAHYDRO-6H-PYRIDAZINO [1,2-A] [1,2] DIAZEPIN-1-CARBOXAMIDE
- 专利标题（中）： 1S- [1-ALPHA（2S *，3R *），9ALPHA] 6,10-二氧代-N-（2-乙氧基-5-氧代四氢呋喃-3-基）-9] [[（1-异喹啉 ）羰基]氨基]甲酰基-6H-吡啶并[1,2-A] [1,2]二氮杂-1-羧酸
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申请号： US09647858申请日： 2000-11-20
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公开(公告)号： US06544977B1公开(公告)日： 2003-04-08
- 发明人: Jean-Yves Godard , Valerie Rognon
- 申请人： Jean-Yves Godard , Valerie Rognon
- 优先权： FR9804367 19980408
- 主分类号： C07D24302
- IPC分类号： C07D24302
![CRYSTALLINE FORMS OF 1S-[1-ALPHA(2S*,3R*), 9ALPHA]6, 10-DIOXO-N-(2-ETHOXY-5-OXO-TETRAHYDRO-3-FURANYL)-9[[(1-ISOQUINOLYL)CARBONYL]AMINO]OCTAHYDRO-6H-PYRIDAZINO [1,2-A] [1,2] DIAZEPIN-1-CARBOXAMIDE](/abs-image/US/2003/04/08/US06544977B1/abs.jpg.150x150.jpg)
摘要：
Two new crystalline forms of 1S-[1alpha(2S*,3R*), 9alpha]6,10-dioxo-N-(2-ethoxy-5-oxo-tetrahydro-3-furanyl)-9 [[(1-isoquiinolyl)carbonyl]amino]octahydro-6H-pyridazino[1,2-a][1,2]diazepin-1-carboxamide (anhydrous or hydrated), their preparation process and the pharmaceutical compositions containing them.
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