发明授权
- 专利标题: Agent for inducing apoptosis
- 专利标题(中): 诱导细胞凋亡的药物
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申请号: US09793654申请日: 2001-02-27
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公开(公告)号: US06548536B2公开(公告)日: 2003-04-15
- 发明人: Mitsunobu Hara , Takayuki Nakashima , Yutaka Kanda , Masami Hamano , Shun-ichi Ikeda , Yuko Uosaki , Yoko Takata , Junji Kanazawa
- 申请人: Mitsunobu Hara , Takayuki Nakashima , Yutaka Kanda , Masami Hamano , Shun-ichi Ikeda , Yuko Uosaki , Yoko Takata , Junji Kanazawa
- 优先权: JP10/246303 19980831; JP11/50629 19990226
- 主分类号: A61K3134
- IPC分类号: A61K3134
摘要:
Agents for inducing apoptosis comprising a tetrocarcin derivative represented by the following formula (I) or a salt thereof as an active ingredient (---- represents a single bond or a double bond; j and k represent 0 or 1; R1 to R3, R7 to R10 and R14 represent a hydrogen atom, a lower alkyl group and the like; R4, R11, R12, R13 and R15 to R18 represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like; R5 and R6 represents a hydrogen atom, a hydroxyl group, a lower alkyl group, a group represented by the following formula (B) (R32 represents a formyl group and the like, R33 to R35 represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like); R19 represents a hydroxyl group, a lower alkoxyl group, a lower alkanoyloxy group and the like). The agents are useful as medicaments for preventive and/or therapeutic treatment of diseases resulting from increased expression of Bcl-2 family proteins, for example, cancers, AIDS and the like.
公开/授权文献
- US20020022598A1 Agent for inducing apoptosis 公开/授权日:2002-02-21