发明授权
US06569661B1 Recombinant &agr;-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
有权
重组α-L-艾杜糖醛酸酶，其制备和纯化方法以及用于治疗由其缺陷引起的疾病的方法
- 专利标题： Recombinant &agr;-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
- 专利标题（中）： 重组α-L-艾杜糖醛酸酶，其制备和纯化方法以及用于治疗由其缺陷引起的疾病的方法
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申请号： US09711202申请日： 2000-11-09
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公开(公告)号： US06569661B1公开(公告)日： 2003-05-27
- 发明人: Minmin Qin , Wai-Pan Chan , Lin Chen , Paul A. Fitzpatrick , John M. Hendstrand , Dan J. Wendt , Gary N. Zecherle , Christopher M. Starr , Emil D. Kakkis
- 申请人： Minmin Qin , Wai-Pan Chan , Lin Chen , Paul A. Fitzpatrick , John M. Hendstrand , Dan J. Wendt , Gary N. Zecherle , Christopher M. Starr , Emil D. Kakkis
- 主分类号： C12Q100
- IPC分类号： C12Q100
摘要：
The present invention provides a recombinant human &agr;-L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human &agr;-L-iduronidase enzyme as well as methods to treat certain genetic disorders including &agr;-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).
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