The present invention provides methods and compositions for promoting wound healing and reducing scar formation. In particular, the present invention provides cyanoacrylate polymer sealants formulated to contain biologically active elemental silver and/or insulin. The invention also provides methods and compositions for delivering silver and/or insulin in combination with cyanoacrylate sealants. In particular, the present invention provides methods and compositions suitable for treatment of wounds in diabetics, normal patients and surgical patients.