发明授权
US06582949B1 Cephaibols: novel antiparasitics from Acremonium tubakii process for their production, and use thereof
有权
Cephaibols：来自Acremonium tubakii方法的新型抗寄生虫药物的生产及其用途
- 专利标题： Cephaibols: novel antiparasitics from Acremonium tubakii process for their production, and use thereof
- 专利标题（中）： Cephaibols：来自Acremonium tubakii方法的新型抗寄生虫药物的生产及其用途
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申请号： US09563505申请日： 2000-05-03
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公开(公告)号： US06582949B1公开(公告)日： 2003-06-24
- 发明人: László Vértesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
- 申请人： László Vértesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
- 优先权： DE19920816 19990505
- 主分类号： C07K708
- IPC分类号： C07K708
摘要：
The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are va; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-Ile-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser (II), wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.