发明授权
US06596734B1 Tetrahydroisoquinoline compounds for use as &bgr;3-adrenoreceptor agonists
失效
用作β3肾上腺素受体激动剂的四氢异喹啉化合物
- 专利标题: Tetrahydroisoquinoline compounds for use as &bgr;3-adrenoreceptor agonists
- 专利标题(中): 用作β3肾上腺素受体激动剂的四氢异喹啉化合物
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申请号: US10269438申请日: 2002-10-11
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公开(公告)号: US06596734B1公开(公告)日: 2003-07-22
- 发明人: Dennis R. Feller , Duane D. Miller
- 申请人: Dennis R. Feller , Duane D. Miller
- 主分类号: C07D22102
- IPC分类号: C07D22102
摘要:
The invention provides compounds of formula: wherein R1 is —NHS(O)mR, wherein R is alkyl, substituted alkyl, alkoxy, substituted alkoxy, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, or substituted heterocycle; X is independently selected from the group consisting of halo, alkyl, substituted alkyl, alkoxy, substituted alkoxy, hydroxy, nitro, amino, and substituted amino; R2 is benzyl or benzyl substituted with one or more substituents selected from the group consisting of halo, CF3, hydroxy, nitro, alkoxy, substituted alkoxy, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, substituted heterocycle, amino, and substituted amino of formula —NHR' or —NR′R′, wherein each R′ is alkyl, substituted alkyl, —C(O)Y, —C(O)NHY, or —C(O)SY, wherein Y is alkyl or substituted alkyl; R3 is H or alkyl; n is 0-3; m is 1-2; p is 1-4; the sum of n and p is 1-4; and pharmaceutically acceptable salts thereof.
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