Drink spout systems for use with drink containers. The drink spout systems are configured to easily pierce a drink container or a seal across an opening in the drink container to access the drink fluid contained within the drink container. The drink spout system may include a valve assembly to regulate the flow of the drink fluid through the drink spout. The drink spout system may additionally or alternatively include a valve assembly that is configured to prevent drink fluid from being unintentionally dispensed from the drink container, such as when the drink container is pierced by the drink spout system or when the drink container is tipped over or dropped. The drink spout system is particularly useful on aseptic drink pouches, aseptic drink boxes, drink bottles and other similar drink containers.