发明授权
- 专利标题: 1-oxa-3,9-diaza-spiro[5,5]undecan-2-ones
- 专利标题(中): 1-氧杂-3,9-二氮杂 - 螺[5,5]十一烷-2-酮
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申请号: US10143431申请日: 2002-05-10
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公开(公告)号: US06599900B2公开(公告)日: 2003-07-29
- 发明人: Hai-Ying Cai , Michael Patrick Dillon , Guido Galley , Annick Goergler , Sabine Kolczewski , Dawn Muszynski Barsy
- 申请人: Hai-Ying Cai , Michael Patrick Dillon , Guido Galley , Annick Goergler , Sabine Kolczewski , Dawn Muszynski Barsy
- 优先权: EP01111644 20010514
- 主分类号: C07D49810
- IPC分类号: C07D49810
摘要:
The invention relates to compounds of the general formula wherein (R1)n is independently from from each other halogen, lower alkyl or lower alkoxy; R2 is hydrogen, lower alkyl, lower halogen-alkyl, —(CH2)m—OH, —(CH2)m—NR2, —(CH2)mO-lower alkyl, —(CH2)m—C(O)—NR2, or is —(CH2)m-6-membered heteroaryl, optionally substituted by one or more lower alkoxy, —(CH2)m-5 or 6-membered not aromatic heterocyclyl, optionally substituted by hydroxy or lower alkyl; R is hydrogen or lower alkyl and may be the same or different in case of R2; n is 0, 1, or 2; m is 0, 1, 2, 3 or 4; and pharmaceutically acceptable acid addition salts thereof. These compounds have a good affinity to the NK-1 receptor and they are therefore suitable for the treatment of diseases, related to this receptor.
公开/授权文献
- US20030004163A1 1-Oxa-3,9-diaza-spiro[5,5]undecan-2-ones 公开/授权日:2003-01-02
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