发明授权
- 专利标题： Adenosine receptor antagonists and methods of making and using the same
- 专利标题（中）： 腺苷受体拮抗剂及其制备和使用方法
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申请号： US09711554申请日： 2000-11-13
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公开(公告)号： US06605600B1公开(公告)日： 2003-08-12
- 发明人: Carol L. Ensinger , James E. Dowling , Russell C. Petter , Gnanasambandam Kumaravel
- 申请人： Carol L. Ensinger , James E. Dowling , Russell C. Petter , Gnanasambandam Kumaravel
- 主分类号： C07D47306
- IPC分类号： C07D47306
摘要：
The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I: R3 is an optionally substituted group selected from: and wherein X1, X2, Z, R1, R2, and R6 are as described in the specification.