发明授权
- 专利标题： Cathecol hydrazone derivatives, process for preparing the same and pharmaceutical composition containing the same
- 专利标题（中）： col腙衍生物，其制备方法以及含有它们的药物组合物
-
申请号： US09959947申请日： 2001-11-13
-
公开(公告)号： US06610715B1公开(公告)日： 2003-08-26
- 发明人: Yong Sik Youn , Myung Xik Xiang , Byoung Chol Suh , Jong Hoon Kim , Kwang Hyuk Lee , Eui Kyung Kim , Jae Kyu Shin , Chung Keun Rhee
- 申请人： Yong Sik Youn , Myung Xik Xiang , Byoung Chol Suh , Jong Hoon Kim , Kwang Hyuk Lee , Eui Kyung Kim , Jae Kyu Shin , Chung Keun Rhee
- 主分类号： A61K31175
- IPC分类号： A61K31175
摘要：
The present invention provides novel cathecol hydrazone derivatives of formula (I) or pharmaceutically acceptable salts thereof, wherein R1 is C1-7 alkyl or C3-7 cycloalkyl; R2 is hydrogen, hydroxy, C1-5 alkyl or —CH2CH2C(═O)NH2; R3 and R4 are independently hydrogen, C1-7 alkyl, —C(═X)—R5, or 2-, 3- or 4-pyridyl, prymidyl or phenyl substituted with one or two selected from a group consisting of halogen, C1-6 alkoxy, nitro, trifluoromethyl, C1-6 alkyl and carboxyl, or R3 and R4 are directly bonded by C3-4 containing oxygen, sulfur or nitrogen to form a heterocyclic ring, X is oxygen, sulfur or NH and R5 is C1-7 alkyl, —NHR6, CONH2 or 2-, 3- or 4-pyridyl, prymidyl or phenyl substituted with one selected from a group consisting of halogen, C1-6 alkoxy, nitrile, trifluoromethyl, C1-6 alkyl and carboxyl, and R6 is hydrogen, hydroxy, NH2, C1-5 alkoxy, C1-5 alkyl, pyridyl or phenyl.