发明授权
- 专利标题： Processes for making- and a new crystalline form of- leflunomide
- 专利标题（中）： 制备和新型结晶形式的来氟米特的方法
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申请号： US09736727申请日： 2000-12-14
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公开(公告)号： US06610718B2公开(公告)日： 2003-08-26
- 发明人: Ilya Avrutov , Neomi Gershon , Judith Aronhime
- 申请人： Ilya Avrutov , Neomi Gershon , Judith Aronhime
- 主分类号： C07D26118
- IPC分类号： C07D26118
摘要：
New leflunomide Form III is disclosed, along with processes for preparing it. The present invention also provides an economic process for preparing leflunomide Form II and a process for preparing leflunomide Form I from leflunomide Form III. Pharmaceutical compositions and dosage forms containing the new form and methods of using them for the treatment of rheumatoid arthritis are also disclosed.