发明授权
- 专利标题: &bgr;-secretase enzyme compositions and methods
- 专利标题(中): β-分泌酶组合物和方法
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申请号: US09724566申请日: 2000-11-28
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公开(公告)号: US06627739B1公开(公告)日: 2003-09-30
- 发明人: John P. Anderson , Guriqbal Basi , Minh Tam Doan , Normand Frigon , Varghese John , Michael Power , Sukanto Sinha , Gwen Tatsuno , Jay Tung , Shuwen Wang , Lisa McConlogue
- 申请人: John P. Anderson , Guriqbal Basi , Minh Tam Doan , Normand Frigon , Varghese John , Michael Power , Sukanto Sinha , Gwen Tatsuno , Jay Tung , Shuwen Wang , Lisa McConlogue
- 主分类号: C07K1640
- IPC分类号: C07K1640
摘要:
Disclosed are various forms of an active, isolated &bgr;-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (&bgr;-APPwt and &bgr;-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate &bgr;-secretase. Inhibitors of &bgr;-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.