Methods for the identification of inhibitors of homocitrate synthase as antibiotics

发明授权

US06632631B1 Methods for the identification of inhibitors of homocitrate synthase as antibiotics 失效

标题翻译：用于鉴定高柠檬酸合酶抑制剂作为抗生素的方法

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专利标题： Methods for the identification of inhibitors of homocitrate synthase as antibiotics
专利标题（中）： 用于鉴定高柠檬酸合酶抑制剂作为抗生素的方法
申请号： US10011200

申请日： 2001-11-09
公开(公告)号： US06632631B1

公开(公告)日： 2003-10-14
发明人: Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd M. DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy K. Mahanty , Huaqin Pan , Amy Skalchunes , Rex W. Tarpey
申请人： Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd M. DeZwaan , Sze-Chung Lo , Maria Victoria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy K. Mahanty , Huaqin Pan , Amy Skalchunes , Rex W. Tarpey
主分类号： C12Q118
IPC分类号： C12Q118

Methods for the identification of inhibitors of homocitrate synthase as antibiotics

摘要：

The present inventors have discovered that homocitrate synthase is essential for fungal pathogenicity. Specifically, the inhibition of homocitrate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, homocitrate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit homocitrate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.

摘要（中）：

本发明人已经发现，高柠檬酸合酶对于真菌致病性是必需的。具体来说，抑制真菌中的高柠檬酸合酶基因表达没有导致成功感染或病变的迹象。因此，高柠檬酸合酶可以用作鉴定抗生素，优选抗真菌剂的靶标。因此，本发明提供了鉴定抑制高柠檬酸合酶表达或活性的化合物的方法。本发明的方法可用于鉴定抗生素，优选抗真菌剂

公开/授权文献

US20030180829A1 METHODS FOR THE IDENTIFICATION OF INHIBITORS OF HOMOCITRATE SYNTHASE AS ANTIBIOTICS 公开/授权日：2003-09-25

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